The association between gastro-oesophageal reflux disease and asthma: a systematic review
Identifieur interne : 001499 ( Main/Exploration ); précédent : 001498; suivant : 001500The association between gastro-oesophageal reflux disease and asthma: a systematic review
Auteurs : B D Havemann [États-Unis] ; C A Henderson [Royaume-Uni] ; H B El-Serag [États-Unis]Source :
- Gut [ 0017-5749 ] ; 2007-12.
Abstract
Background and aim: Gastro-oesophageal reflux disease (GORD) has been linked to a number of extra-esophageal symptoms and disorders, primarily in the respiratory tract. This systematic review aimed to provide an estimate of the strength and direction of the association between GORD and asthma. Methods: Studies that assessed the prevalence or incidence of GORD in individuals with asthma, or of asthma in individuals with GORD, were identified in Medline and EMBASE via a systematic search strategy. Results: Twenty-eight studies met the selection criteria. The sample size weighted average prevalence of GORD symptoms in asthma patients was 59.2%, whereas in controls it was 38.1%. In patients with asthma, the average prevalence of abnormal oesophageal pH, oesophagitis and hiatal hernia was 50.9%, 37.3% and 51.2%, respectively. The average prevalence of asthma in individuals with GORD was 4.6%, whereas in controls it was 3.9%. Pooling the odds ratios gave an overall ratio of 5.5 (95% CI 1.9–15.8) for studies reporting the prevalence of GORD symptoms in individuals with asthma, and 2.3 (95% CI 1.8–2.8) for those studies measuring the prevalence of asthma in GORD. One longitudinal study showed a significant association between a diagnosis of asthma and a subsequent diagnosis of GORD (relative risk 1.5; 95% CI 1.2–1.8), whereas the two studies that assessed whether GORD precedes asthma gave inconsistent results. The severity–response relationship was examined in only nine studies, with inconsistent findings. Conclusions: This systematic review indicates that there is a significant association between GORD and asthma, but a paucity of data on the direction of causality.
Url:
DOI: 10.1136/gut.2007.122465
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This systematic review aimed to provide an estimate of the strength and direction of the association between GORD and asthma. Methods: Studies that assessed the prevalence or incidence of GORD in individuals with asthma, or of asthma in individuals with GORD, were identified in Medline and EMBASE via a systematic search strategy. Results: Twenty-eight studies met the selection criteria. The sample size weighted average prevalence of GORD symptoms in asthma patients was 59.2%, whereas in controls it was 38.1%. In patients with asthma, the average prevalence of abnormal oesophageal pH, oesophagitis and hiatal hernia was 50.9%, 37.3% and 51.2%, respectively. The average prevalence of asthma in individuals with GORD was 4.6%, whereas in controls it was 3.9%. Pooling the odds ratios gave an overall ratio of 5.5 (95% CI 1.9–15.8) for studies reporting the prevalence of GORD symptoms in individuals with asthma, and 2.3 (95% CI 1.8–2.8) for those studies measuring the prevalence of asthma in GORD. One longitudinal study showed a significant association between a diagnosis of asthma and a subsequent diagnosis of GORD (relative risk 1.5; 95% CI 1.2–1.8), whereas the two studies that assessed whether GORD precedes asthma gave inconsistent results. The severity–response relationship was examined in only nine studies, with inconsistent findings. Conclusions: This systematic review indicates that there is a significant association between GORD and asthma, but a paucity of data on the direction of causality.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Oxfordshire</li><li>Texas</li></region><settlement><li>Oxford</li></settlement></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Havemann, B D" sort="Havemann, B D" uniqKey="Havemann B" first="B D" last="Havemann">B D Havemann</name></region><name sortKey="El Serag, H B" sort="El Serag, H B" uniqKey="El Serag H" first="H B" last="El-Serag">H B El-Serag</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Henderson, C A" sort="Henderson, C A" uniqKey="Henderson C" first="C A" last="Henderson">C A Henderson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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